Pine Bluffs is a town in eastern Laramie County, Wyoming, United States. It is located on the county's border with Nebraska. Pine Bluffs is part of the Cheyenne, Wyoming, Metropolitan Statistical Area. As of the 2020 census, Pine Bluffs had a population of 1,172. It was first known as Rock Ranch, but the name was changed by railroad officials for the pines on the nearby bluffs.