Appleton is a city, and the county seat of Outagamie County, Wisconsin, United States, with small portions extending into Calumet and Winnebago counties. Located on the Fox River north of Lake Winnebago, it is 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. The city had a population of 75,644 at the 2020 census, making it the sixth-most populous city in Wisconsin. The Appleton metropolitan statistical area had 243,147 residents. Appleton is part of the broader Fox Cities region.