Rainelle is a town on the western edge of Greenbrier County, West Virginia, United States. It sits at the base of Sewell Mountain and Sims Mountain, and is bisected by the Meadow River. The only means of transportation to and from Rainelle are roads; primarily US 60 and WV 20, which merge on the western end of the town, and the James River and Kanawha Turnpike, which enters from the south. The population was 1,190 at the 2020 census.