Nacogdoches is a city in East Texas and the county seat of Nacogdoches County, Texas, United States. As of the 2020 census, Nacogdoches had a population of 32,147. Stephen F. Austin State University is located in Nacogdoches and specializes in forestry and agriculture. Nacogdoches is also known as "The Oldest Town in Texas". Its sister city is Natchitoches, Louisiana.