Mesquite is a city in the U.S. state of Texas, located in Dallas County with portions extending into Kaufman County. The population was 150,108 at the 2020 census, making it the 22nd-most populous city in Texas. Mesquite is positioned at the crossroads of four major highways, making locations such as downtown Dallas, Lake Ray Hubbard, Dallas Love Field, and DFW International Airport accessible.