Bluffton is a town in southern Beaufort County, South Carolina, United States. The population as of the 2020 census was 27,716, an increase of over 120% since the 2010 census, making it the 17th-most populous municipality and one of the fastest growing municipalities in South Carolina. It is primarily located around U.S. Route 278 between Hilton Head Island and Interstate 95. Bluffton is a principal town within the Hilton Head Island metropolitan area.