Saluda is a city in Polk and Henderson counties in the U.S. state of North Carolina. The population was 631 at the 2020 census. Saluda is famous for sitting at the top of the Norfolk Southern Railway's Saluda Grade, which was the steepest main line standard-gauge railway line in the United States until Norfolk Southern ceased operations on the line in 2001. Saluda is close to the South Carolina state line, between Asheville, North Carolina, and Spartanburg, South Carolina.