Missoula is a city in and the county seat of Missoula County, Montana, United States. It is located along the Clark Fork River near its confluence with the Bitterroot and Blackfoot rivers in western Montana and at the convergence of five mountain ranges, and thus it is often described as the "hub of five valleys". It is the second-most populous city in Montana with a population of 73,489 at the 2020 census and estimated at 78,204 in 2024, while the Missoula metropolitan area has an estimated 128,000 residents. Missoula is home to the University of Montana, a public research university.