St. Joseph is a city in and the county seat of Buchanan County, Missouri, United States. Located on the Missouri River, it is the principal city of the St. Joseph Metropolitan Statistical Area, which includes Buchanan, Andrew, and DeKalb counties in Missouri and Doniphan County, Kansas. As of the 2020 census, St. Joseph had a population of 72,473, making it the 8th most populous city in the state, and the 3rd most populous in Northwest Missouri. St. Joseph is located roughly 30 miles (48 km) north of the Kansas City, Missouri city limits and approximately 125 miles (201 km) south of Omaha, Nebraska.