Chillicothe is a city in and the county seat of Livingston County, Missouri, United States. The population was 9,107 at the 2020 census. The name "Chillicothe" is Shawnee for "big town". Chillicothe is known as "The Home of Sliced Bread". For many years its schools were segregated and African American students attended what eventually became known as Garrison School, named after William Lloyd Garrison.