Cape Girardeau is a city in Cape Girardeau and Scott counties in the U.S. state of Missouri. The population was 39,540 at the 2020 census, making it the 17th-largest city in the state. It is a principal city of the Cape Girardeau–Jackson metropolitan area with 97,517 residents. Cape Girardeau is the economic center of southeastern Missouri and the home of Southeast Missouri State University. It is located approximately 100 miles (160 km) southeast of St. Louis and 150 miles (240 km) north of Memphis, Tennessee.