Gladstone is a city in Delta County in the Upper Peninsula of the U.S. state of Michigan. First settled in 1877, Gladstone's original name was Minnewasca. The population was 5,257 according to the 2020 census, The U.S. Highways 2 and 41 run concurrently through the city, connecting it to various other communities in the Upper Peninsula of Michigan. The city of Escanaba lies roughly 14 km (9 mi) to the south.