Maysville is a home rule-class city in Mason County, Kentucky, United States, and is the county seat of Mason County. The population was 8,873 as of the 2020 census. Maysville is on the Ohio River, 66 miles (106 km) northeast of Lexington. Two bridges cross the Ohio from Maysville to Aberdeen, Ohio: the Simon Kenton Memorial Bridge built in 1931 and the William H. Harsha Bridge built in 2001.