Keokuk is a city in and a county seat of Lee County, Iowa, United States. It is Iowa's southernmost city. The population was 9,900 at the time of the 2020 census. The city is named after the Sauk chief Keokuk. It is in the extreme southeast corner of Iowa, where the Des Moines River meets the Mississippi. Keokuk is also the home of Keokuk National Cemetery.