West Lafayette is a city in Tippecanoe County, Indiana, United States. The population was 44,595 at the 2020 census. West Lafayette sits across the Wabash River from its sister city, Lafayette, and is a college town, home to Purdue University. It is the most densely populated city in Indiana, located 65 miles (105 km) northwest of Indianapolis and 113 miles (182 km) southeast of Chicago.